孟德尔随机化研究：谷氨酰胺如何降低晚发型重症肌无力风险？

Results: Genetically predicted glutamine levels were significantly negatively associated with the risk of LOMG (IVW: OR = 0.64, 95% CI: 0.46 to 0.87, P = 0.005). The results were robust using weighted median and leave-one-out analyses, with no evidence of horizontal pleiotropy (MR-Egger intercept P = 0.350). Bayesian colocalization analysis identified moderate support for a shared causal variant at the rs2039098 locus (PP4 = 0.645), with lower support for different causal variants (PP3 = 0.112). Citrulline was also negatively associated with LOMG (OR = 0.001, P = 0.009), and testosterone with MG (OR = 0.30, P = 0.043); however, these associations were limited by a small number of instrumental variables or inconsistent results. Lactate was significantly positively associated with the risk of MG (OR = 5.21, P = 0.031).