- Bioinformatics Analysis of Skeletal Muscle Metabolism Improvement in T2DM Patients by Exercise
A total of 81 differentially expressed genes (34 upregulated, 47 downregulated) were identified from the dataset GSE205891, and 100 differentially expressed genes (41 upregulated, 59 downregulated) were identified from the dataset GSE230002. Among these, 26 genes were significantly differentially expressed in both datasets. GO and KEGG enrichment analyses were performed on the intersecting genes, and a PPI protein interaction network was constructed for these genes. The top 10 key genes were identified as MYH1, MYH4, MYH8, MSTN, ACTN3, MYH13, LEP, FOS, SCD, and CALML6. Notably, MSTN, a common myokine, has received significant attention in the mechanisms by which exercise intervention improves T2DM.
