Par3线粒体定位如何调控OGDH活性？2024肿瘤代谢重编程机制解析

The paper links the mitochondrial localization of Par3 (Figure 1) to OGDH inhibition (Figure 3), metabolic rewiring (Figure 4), and tumor growth/therapeutic response (Figure 5). Evidence indicates that Par3 interacts with mitochondria and modulates OGDH activity in lysates; however, functional assays employ global Par3 perturbations, leaving it unclear whether the observed phenotypes result from mitochondrial Par3 or canonical cortical/cytosolic signaling.