光动力疗法与Nd:YAG热消融治疗食管癌的比较研究

2025-05-13 MedSci xAi 发表于广东省
本文对比了光动力疗法(PDT)与Nd:YAG热消融在晚期食管癌患者缓解治疗中的效果与安全性。研究显示,PDT在缓解率与吞咽改善方面优于Nd:YAG,但光敏反应与治疗相关不良事件发生率较高。
A previous study comparing Photofrin-mediated photodynamic therapy (PDT) versus Nd:YAG thermal ablation for palliative treatment in patients with advanced esophageal cancer and dysphagia [10] showed that at 1 month, the es-ORR was 32% and 20%, respectively, and the proportion of patients with improved dysphagia was 35% and 29%. In terms of safety, the TEAE incidence rates were 92% and 82%, respectively, and the AE-related mortality rates were 24% and 21%. Among patients treated with PDT, all patients avoided sunlight exposure for 1-2 months, and 19% of patients in the PDT group experienced photosensitivity reactions due to sun exposure.
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