谷氨酰胺与LOMG遗传关联：贝叶斯共定位分析揭示rs2039098位点共享因果变异

To further evaluate whether there are shared causal variants between glutamine and late-onset myasthenia gravis (LOMG), we performed Bayesian colocalization analysis using 39 independent instrumental variable SNPs associated with glutamine. The results showed moderate support for shared causal variants at the rs2039098 locus (20q13.32 region) (PP4=0.645), with lower support for different causal variant models (PP3=0.112). This finding is consistent with the protective MR results of glutamine on LOMG. A total of 4,749 SNPs in this region were analyzed, suggesting a potential common genetic basis between glutamine and LOMG at this locus, as shown in Figure 6. Additionally, higher colocalization support was observed at the rs117643180 locus (17p13.3 region) (PP3=0.758), but PP4 was low (0.017), indicating that this locus may have shared genetic association signals, although the causal variant model remains unclear. Detailed results are provided in Supplementary Figure S4. No significant associations were found at the other loci.