COPD肠道菌群变化如何影响肺炎症？2024菌群失调机制详解

In addition to the significant differences in bacterial genera mentioned above, this study also observed certain trends in abundance changes between the two groups. Compared with the NC group, the MC group showed an increasing trend in the abundance of potentially pathogenic bacteria such as the Escherichia-Shigella, Streptococcus, and Prevotella genera; while the abundance of potentially beneficial bacteria such as the Roseburia, Phascolarctobacterium, and Alistipes genera showed a decreasing trend. Roseburia is an important butyrate-producing bacterium in the gut, and butyrate provides energy to colonocytes, maintains intestinal barrier function, and has anti-inflammatory and immune-modulating effects. The decreasing trend in Roseburia may indicate a reduction in gut short-chain fatty acids (SCFAs) levels, leading to impaired intestinal barrier function, which could promote the entry of inflammatory mediators into circulation and exacerbate lung inflammation. Although these trends did not reach statistical significance, their directionality is consistent with the dysbiosis characteristics indicated by the significantly different genera, providing additional insights into the gut microbiota features of COPD patients.