如何通过Monoglobus菌属评估肠道健康？2025肠肺轴机制最新研究

The boxplot analysis of differential species showed that the abundance of the genus Monoglobus and the CAG-352 genus was significantly higher in the MPH group compared to the MC group (P < 0.05). LEfSe analysis further confirmed that the significantly enriched biomarkers in the MPH group were the order Monoglobales, the family Monoglobaceae, the genus Monoglobus, and the CAG-352 genus, which can serve as characteristic differential taxa after the intervention with Bu Xu Ping Chuan膏 (a traditional Chinese medicine formulation). The abundance of Monoglobus and CAG-352 in the MPH group was significantly increased (P < 0.05), and LEfSe analysis further confirmed these two taxa as characteristic biomarkers of the MPH group, with Monoglobus being the core differential genus whose abundance significantly increased after the intervention (P = 0.008). Monoglobus belongs to the phylum Firmicutes and is an important member of short-chain fatty acid (SCFA)-producing bacteria, primarily producing acetic acid, propionic acid, and butyric acid. SCFAs are important metabolites of the gut microbiota and have various physiological functions. They serve as an energy source for intestinal epithelial cells, promote the repair of the intestinal mucosa, enhance intestinal barrier function, reduce endotoxin leakage, and exhibit significant anti-inflammatory effects by inhibiting intestinal mucosal inflammation and regulating systemic immune function. Through the gut-lung axis, SCFAs also modulate pulmonary inflammatory responses, reducing airway inflammation and lung function impairment in COPD patients. Studies have confirmed that the upregulation of Monoglobus abundance is closely related to gut health, as it can exert anti-inflammatory and immunomodulatory effects through the production of SCFAs, maintaining the balance of the gut microbiota and serving as a potential biomarker for assessing gut health status.