1.4 Preparation of Radioactive Nuclide Patches
To achieve personalized and precise dosing in nuclide patch therapy, this study adopted an integrated "3D scanning and modeling - 3D printing conformal" process. First, a high-precision three-dimensional point cloud data of the lesion area was obtained using a 3D scanner. This data was then processed with specialized software to generate an STL format file for printing. The file was subsequently imported into slicing software (Ultimaker Cura), where parameters such as layer height and infill density were set, and a G-code (.gcode) file for controlling the printing path was generated. The printing process was carried out on a 3D printer (Eazao Zero) with a UV lamp fixed above the printing platform. Before printing, a uniform hydrogel precursor solution containing Na2H32PO4 or 90Y microspheres was injected into a pre-cooled cartridge. During printing, the printer followed the G-code instructions, operating with a nozzle diameter of 1.6 mm and a printing speed of 25 mm/s. The extruded hydrogel filaments were immediately exposed to UV light upon deposition, achieving simultaneous curing and layer-by-layer formation, ultimately resulting in a conformal radioactive nuclide patch.
