健身代谢物如何影响重症肌无力？2025遗传证据与谷氨酰胺保护机制解析

5. Conclusion In summary, this study provides genetic evidence for the causal relationship between fitness and related metabolites and myasthenia gravis (MG), particularly its late-onset subtype. Among these, glutamine shows the most robust protective effect against late-onset MG, and colocalization analysis further identified a moderate shared signal at the rs2039098 locus, suggesting its potential role in immune regulation and the maintenance of peripheral immune homeostasis. The protective signals of citrulline and testosterone should be interpreted with caution, while lactate is identified as a potential risk factor. These findings highlight the importance of fitness supplements and related metabolites in the pathogenesis of MG, although some results still require validation through larger-scale, more diverse GWAS data. Additionally, exploring intervention strategies based on metabolites such as glutamine, tailored to the specific immune senescence characteristics of late-onset MG, may offer new approaches for personalized prevention and early intervention.