代谢物如何影响重症肌无力？2022孟德尔随机化研究揭示谷氨酰胺保护机制

In summary, this study provides genetic evidence for the causal relationship between fitness-related metabolites and MG as well as its late-onset form (LOMG) using Mendelian randomization methods. Among the four candidate substances, glutamine showed the most robust association with LOMG, with its protective effect supported by multiple methods, sensitivity analyses, and colocalization analyses. It is likely to exert protective effects on LOMG through multiple pathways, including immune regulation and skeletal muscle metabolism support. Citrulline and testosterone exhibited potential protective signals but require cautious interpretation due to limitations in the number of instrumental variables or consistency of results. Lactic acid was identified as a potential risk factor for MG. From a clinical perspective, glutamine, as a safe and accessible fitness supplement, may have potential preventive value for high-risk populations with immune senescence characteristics associated with LOMG (DOI: 10.3389/fimmu.2022.986847). We speculate that supplementing with similar fitness supplements could increase the concentration of corresponding substances in the body, thereby indirectly influencing the onset of MG.