PLB1004药代动力学分析：240mg与320mg剂量组对比

A total of 118 participants were included in the PK analysis, with 86 in the 240 mg dose group and 32 in the 320 mg dose group. The mean (±SD) trough concentrations of PLB1004 in the plasma of participants at the 240 mg dose level on Day 1 of Cycles 2, 3, and 5 were 109.73±76.09, 112.47±86.46, and 92.79±64.74 ng/mL, respectively. For participants at the 320 mg dose level, the mean (±SD) trough concentrations of PLB1004 in the plasma on Day 1 of Cycles 2, 3, and 5 were 149.12±113.83, 121.14±88.91, and 107.77±61.39 ng/mL, respectively. The trough concentrations at the same dose level across cycles were similar, indicating that steady-state drug concentrations were achieved by Cycle 2. The trough concentrations in the 320 mg dose group were slightly higher than those in the 240 mg dose group, generally proportional to the dose (Supplementary Figure 3).