MICT与HIIT如何调节糖尿病小鼠线粒体质量？2024分子机制深度解析

MICT and HIIT Regulate Skeletal Muscle Mitochondrial Quality Control in db/db Mice: Compared to the NC group, the mtDNA copy number in the DC group significantly decreased (P<0.01). Compared to the DC group, the mtDNA copy number in both the MICT group and the HIIT group significantly increased (P<0.001). Compared to the MICT group, the mtDNA copy number in the HIIT group significantly increased (P<0.001). Compared to the NC group, the protein expression of NRF2, TFAM, OPA1, MFN2, DRP1, PINK1, and PARKIN in the DC group significantly decreased (P<0.01, P<0.001). Compared to the DC group, the protein expression of NRF2, TFAM, OPA1, MFN2, DRP1, PINK1, and PARKIN in both the MICT group and the HIIT group significantly increased (P<0.001). Compared to the MICT group, the protein expression of NRF2, TFAM, OPA1, DRP1, PINK1, and PARKIN in the HIIT group significantly increased (P<0.05, P<0.01, P<0.001), while the protein expression of MFN2 did not show a significant change.