乳酸升高如何增加重症肌无力风险？2024孟德尔随机化研究解读

In contrast to the aforementioned protective factors, lactic acid has been identified as a risk factor. The inverse variance-weighted (IVW) analysis showed that genetically predicted lactic acid levels were significantly positively associated with myasthenia gravis risk (OR = 5.21, 95% CI: 1.16 to 23.33, P = 0.031), indicating that each standard deviation increase in lactic acid is associated with approximately a 4.2-fold increase in the risk of myasthenia gravis. The weighted median method (OR = 9.86, 95% CI: 1.27 to 76.77, P = 0.029) also supported the risk effect of lactic acid, while the MR-Egger regression showed an opposite direction of effect. All these data are presented in Table 1.