16S rDNA测序如何揭示COPD虚证患者肠道菌群特征？2025微生物组研究新发现

Through 16S rDNA sequencing, the intestinal microbiota characteristics of patients with stable COPD and deficiency syndrome were initially elucidated at both the diversity and structure levels of the microbial community. Venn diagram analysis showed that the MC group had 421 unique OTUs, while the NC group had 716 unique OTUs. The unique OTUs reflect a certain degree of inter-individual heterogeneity in the gut microbiota within the patient population with stable COPD and deficiency syndrome. This suggests that although each group has its own unique microbial communities, the majority of bacterial taxa are shared. This phenomenon may be related to factors such as disease duration, medication history, lifestyle habits, and genetic background. This observation indicates that when interpreting the results of microbiota-related studies, it is essential to consider the potential impact of individual differences on overall conclusions.