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- Briefly summarize the results and clinical significance of this study. This study compared the efficacy and safety of DVDMS-PDT (dihydroxy-2-methyl-3(1H)-pyridinone-4-propionic acid photodynamic therapy) with investigator-chosen treatments in patients with advanced esophageal cancer who had dysphagia and whose disease progressed after standard prior therapy, leaving them with limited treatment options. The results showed that compared to investigator-chosen treatments, DVDMS-PDT significantly improved endoscopic outcomes, as well as patient progression-free survival (PFS), dysphagia symptoms, and quality of life. Although there was no significant difference in overall survival (OS) between the two groups, sensitivity analyses adjusting for crossover effects suggested a potential survival benefit with DVDMS-PDT. In terms of safety, the DVDMS-PDT group experienced fewer grade ≥3 treatment-emergent adverse events and fewer treatment-related deaths, with a lower incidence of phototoxicity. These findings suggest that in patients with advanced esophageal cancer and dysphagia who have limited treatment options, DVDMS-PDT not only improves symptoms but also exerts an antitumor effect, providing an effective and safe therapeutic option for these patients.
