To further evaluate the robustness of the causal effect estimates, we conducted a series of sensitivity analyses. The MR-Egger intercept test did not detect significant directional pleiotropy (intercept = -0.0134, SE = 0.0142, P = 0.350), supporting the reliability of the MR analysis results. The MR-PRESSO global test further supported this conclusion, with no significant horizontal pleiotropy detected (P = 0.244).
孟德尔随机化敏感性分析：如何验证因果效应稳健性？MR-Egger与MR-PRESSO检验详解
本文详解孟德尔随机化敏感性分析方法，重点解析MR-Egger截距检验（截距=-0.0134，P=0.350）和MR-PRESSO全局检验（P=0.244）在检测方向性和水平多效性中的应用，为因果效应估计的稳健性验证提供方法学指导。
与梅斯小智对话
