补虚平喘膏如何通过肺肠轴调控COPD？2024肠道菌群功能代谢机制详解

The functional metabolism of the gut microbiota is at the core of its physiological effects. The gut microbiota can influence host health through structural changes and participate in the host's material metabolism and immune regulation by altering metabolic products and functional pathways, thereby affecting the onset and progression of diseases. These functional metabolic changes are largely consistent with the abundance changes of key differential bacterial taxa, suggesting that Bu Xu Ping Chuan膏 (a traditional Chinese medicine) improves the pathological and physiological conditions of COPD patients by modulating the structure of the gut microbiota, which is a specific manifestation of the lung-gut axis theory in this study. COG functional difference analysis showed that the abundance of 8 functional genes was significantly reduced in the MPH group. Among these, changes in core functional genes have clear physiological significance. The abundance of COG4570 (related to DNA repair), COG0229 (related to antioxidant function), and COG4403 (related to antimicrobial peptide synthesis) was reduced, indicating that Bu Xu Ping Chuan膏 can regulate the core functions of the gut microbiota, preventing the over-activation of these functions. Over-activation of DNA repair function may be associated with enhanced stress responses in the microbial community, while over-activation of antioxidant function may reflect abnormal intestinal oxidative stress status. Excessive synthesis of antimicrobial peptides could potentially disrupt the balance and stability of the gut microbiota.