DVDMS-PDT治疗食管癌疗效评估

In this study, the efficacy evaluation criteria were based on endoscopic assessment, with the local treatment effect evaluated according to the changes in the diameter of the most narrowed segment of the esophagus. The results showed that the primary endpoint of esophageal objective response rate (es-ORR) was significantly higher in the DVDMS-PDT group compared to the TPC group, and the benefit was consistent across different subgroups, including patients previously treated with radiotherapy. This suggests that DVDMS-PDT treatment significantly alleviated the compression of the esophageal primary tumor on the lumen. Additionally, the es-ORR values in this study were higher than those achieved with Photofrin-mediated PDT, and the criteria for complete response (CR) and partial response (PR) in this study were more stringent than those for Photofrin-mediated PDT, indicating that DVDMS as a photosensitizer may have potential advantages [10]. The significantly prolonged esophageal time to progression (es-TTP) and esophageal progression-free survival (es-PFS) in the DVDMS-PDT group further suggest the significant effect of DVDMS-PDT in alleviating the compression of the esophageal primary tumor on the lumen.