肌无力研究突破：健身补充剂如何影响免疫代谢调控？2024最新发现

The primary strengths of this study lie in its focus on fitness and related metabolites, examining the daily intervenable factor of fitness supplements in combination with the unique immune aging characteristics of LOMG for subtype analysis. This approach provides a new perspective on the role of immune metabolic regulation in the pathogenesis of MG. Additionally, Bayesian colocalization analysis revealed moderate shared signals at the rs2039098 locus, further enhancing the credibility of causal inference. However, the study also has certain limitations: the number of instrumental variables for citrulline is insufficient, the consistency of testosterone results is suboptimal, and reverse MR validation was not performed for testosterone and lactate. Moreover, GWAS data primarily come from European populations, and caution is needed when generalizing the findings. We anticipate the accumulation of larger-scale and more diverse population GWAS data to further validate the discoveries of this study and to explore the specific mechanisms by which these metabolites contribute to the pathogenesis of MG.