重症肌无力双向MR分析：2024反向因果关系验证方法详解

To further evaluate potential reverse causality, we conducted a bidirectional Mendelian randomization (MR) analysis. The results showed that genetically predicted risk of myasthenia gravis was not significantly associated with glutamine levels (β = 0.003, P = 0.714) or citrulline levels (β = 0.005, P = 0.523), indicating no evidence of reverse causality. Detailed results are provided in Supplementary Table S2. For testosterone and lactate, due to the application of the same instrument variable selection criteria for the outcome GWAS data in the bidirectional MR analysis, an insufficient number of SNPs were obtained, thus precluding effective bidirectional MR validation.