The safety profile was analyzed in this study. In the current research, adverse events (AEs) related to treatment of physician’s choice were primarily hematologic toxicities. The most common AEs associated with DVDMS were lymphocyte counts, while the most frequent AEs related to photodynamic therapy (PDT) were chest pain. Compared to the safety results reported in previous clinical evidence for PDT in esophageal cancer and the Phase I and II studies of DVDMS-PDT, no new safety risks were identified [12, 17]. In this study, the incidence of photosensitivity events was low, and the positivity rate of photosensitivity tests was less than 5% by 28 days post-treatment, which is a significant improvement over the need for light avoidance for 1-2 months with Photofrin-mediated PDT [18-20].