专业翻译:DVDMS-PDT与TPC治疗不良反应对比分析

2025-05-13 MedSci xAi 发表于广东省
本文详细对比DVDMS-PDT与TPC治疗中的不良反应,依据2025最新临床数据,分析贫血、胸痛、体重减轻等常见症状,并探讨光动力疗法的潜在风险与应对策略。
According to Table 3, the most common treatment-emergent adverse events (TEAEs) in the DVDMS-PDT group were anemia (42 cases, 34.15%), chest pain (39 cases, 31.71%), weight loss (37 cases, 30.08%), nausea (34 cases, 27.64%), and decreased lymphocyte count (34 cases, 27.64%). In the TPC group, the most common TEAEs were decreased white blood cell count (27 cases, 45.76%), anemia (20 cases, 33.90%), decreased neutrophil count (16 cases, 27.12%), nausea (15 cases, 25.42%), and diarrhea (12 cases, 20.34%). According to Supplemental Table 2, the results of treatment-related adverse events (TRAEs) and PDT-related TRAEs are described as follows: In the DVDMS-PDT group, 12 cases (9.76%) of TEAEs led to death, of which 6 were related to photodynamic therapy (PDT), including hematemesis (1 case), esophageal bleeding (1 case), esophageal mediastinal fistula (1 case), and unexplained death (2 cases), and pulmonary inflammation (1 case). In the TPC group, 9 cases (15.25%) of TEAEs led to death, of which 5 were treatment-related, including bone marrow suppression (2 cases), unexplained death (2 cases), and chest discomfort (1 case). According to Table 4, the description of phototoxicity is provided.
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