Title Page

Article Title: Should be concise and clearly reflect the core issue and method of the study.

Authors' Names and Affiliations.

Corresponding Author Contact Information.

Keywords (3-5 keywords for indexing and searching purposes).

Abstract

Background: A brief introduction to the background and purpose of the study.

Methods: Description of the study design, main research methods, and assessment indicators.

Results: A brief overview of the expected results.

Conclusion: The potential impact and significance of the study.

Word Limit: Typically around 250 words.

Keywords

3-5 Keywords.

Main Text

1. Introduction

Background Information: An overview of the background of the research field, highlighting the significance of the study.

Research Question: Clearly state the scientific question or hypothesis to be addressed.

Objectives and Hypotheses: Clarify the research objectives and propose research hypotheses.

2. Study Protocol

2.1 Study Design:

Briefly describe the study design (e.g., observational study, experimental study, cohort study, etc.).

Participants:

Inclusion and Exclusion Criteria.

Source of Study Subjects (e.g., hospitals, communities, volunteers, etc.).

Ethical Considerations (including patient informed consent, hospital ethics approval).

Registration Number

2.2 Research Methods:

Describe the specific methods and steps of the study.

Data Collection Methods (including questionnaires, interviews, laboratory tests, etc.).

Data Management Plan (data entry, storage, confidentiality, etc.).

2.3 Sample Size and Sampling Methods:

Describe the method and rationale for sample size calculation.

Sampling Methods (random sampling, stratified sampling, etc.).

2.4 Data Analysis Plan:

Describe the statistical methods, indicating the primary and secondary analysis approaches.

Show how to handle dropouts, missing data, and bias.

2.5 Quality Control and Quality Assurance:

Describe the quality control measures in the study.

Quality Assurance Plan (e.g., training, supervision, auditing, etc.).

3. Expected Results

3.1 Primary Outcome Measures: Clearly list the main clinical outcome measures.

3.2 Secondary Outcome Measures: Describe the secondary outcomes and their assessment methods.

4. Discussion

4.1 Study Significance: Discuss the potential significance of the study and its contribution to existing literature.

4.2 Study Limitations: Anticipate possible study limitations and challenges.

4.3 Potential Impact of the Study: Discuss the potential impact of the study results on clinical practice and future research.

5. Acknowledgments

Thanks to funders, assistants, research participants, etc.

6. Conflict of Interest Statement

Clearly state any potential conflicts of interest for all participants.

7. References

A formatted reference list according to journal requirements.

8. Appendix (if applicable)

Additional or supplementary data of the study (e.g., intervention manuals, questionnaires, etc.).